Semester 2

๐Ÿ’ŠPharmacology

Not memorization. Pattern recognition with a body count.

Pharm breaks people because they try to memorize 400 drugs. You don't. You memorize about 20 suffixes, a handful of antidotes, and the labs that make you hold a dose. Everything else is a variation on a theme you already know.

Real talk about this course

  • โ€ขSuffixes carry the class. Learn the ending, get the whole family for free.
  • โ€ขThe exam rarely asks 'what does this drug do.' It asks 'what do you assess before you give it.'
  • โ€ขEvery high-alert drug has a lab and an antidote. If you know both, you're unbothered.
  • โ€ขDosage calc questions are worth the same as content questions and are 100% winnable. Do them last, do them slow.

Grade savers ๐Ÿ‘‘

  • Before giving anything cardiac: check apical pulse and BP.
  • Before giving anything nephrotoxic: check creatinine/BUN.
  • Before giving anything that thins blood: check the matching lab (PT/INR, aPTT, platelets).
  • 'Hold and notify' is the right answer more often than students think.

Suffix decoding โ€” the whole class in one ending

You will meet drugs you've never seen on the exam. The ending tells you the class, the class tells you the assessment.

Memory trick

-olol = beta blocker (hold HR<60). -pril = ACE inhibitor (cough, angioedema, Kโบ up). -sartan = ARB (no cough). -dipine = CCB (edema, hypotension). -statin = cholesterol (LFTs, muscle pain). -azole = antifungal. -cillin = penicillin. -mycin = aminoglycoside (nephro + ototoxic). -prazole = PPI. -tidine = H2 blocker. -pam/-lam = benzo (flumazenil). -osin = alpha blocker (first-dose syncope).

You don't know 400 drugs. You know 20 endings and you're fabulous.

Antidotes you will absolutely be asked

Free points if memorized, guaranteed miss if not.

Memory trick

Heparin โ†’ protamine sulfate. Warfarin โ†’ vitamin K. Opioids โ†’ naloxone. Benzos โ†’ flumazenil. Acetaminophen โ†’ acetylcysteine. Magnesium โ†’ calcium gluconate. Digoxin โ†’ digoxin immune Fab. Iron โ†’ deferoxamine.

Pair them like couples. Heparin and protamine are a toxic situationship.

The hold parameters that keep you employed

'Which action does the nurse take before administering' is the most common pharm stem in existence.

Memory trick

Digoxin: apical pulse 1 full minute, hold if <60 (adult). Beta blocker: hold HR<60 or SBP<90. Metformin: hold 48h around IV contrast. Warfarin: INR goal 2โ€“3, hold if higher. Heparin: aPTT 1.5โ€“2.5ร— control. Insulin: check glucose. Vancomycin: trough before the dose, watch creatinine.

Therapeutic ranges worth memorizing

Narrow-window drugs are exam favorites because the margin for error is real.

Memory trick

Digoxin 0.5โ€“2 ng/mL. Lithium 0.6โ€“1.2 mEq/L. Phenytoin 10โ€“20 mcg/mL. Theophylline 10โ€“20 mcg/mL. Vancomycin trough 10โ€“20 mcg/mL. Magnesium (OB) 4โ€“7 mEq/L.

Lithium and dehydration are enemies. Steady salt, steady water, steady level.

Insulin timing โ€” onset is the question

Peak time is when hypoglycemia happens, and that's what they ask.

Memory trick

Lispro/aspart: onset 15 min, peak ~1 h โ€” food must be in front of them. Regular: 30 min / peak 2โ€“4 h โ€” the only IV insulin. NPH: onset 1โ€“2 h / peak 4โ€“12 h โ€” cloudy. Glargine: no peak, never mix, once daily.

Clear before cloudy when mixing โ€” RN before NPH. Air in cloudy first, though.

Toxicity signs that show up as 'the patient reportsโ€ฆ'

The stem describes a symptom, you have to name the drug.

Memory trick

Ringing in the ears = aspirin (salicylism) or aminoglycoside. Yellow-green halos = digoxin. Fine tremor + polyuria = lithium. Gingival hyperplasia = phenytoin. Dry mouth, can't pee, can't see, can't spit = anticholinergics. Muscle pain + dark urine = statin rhabdo.

Halos aren't a religious experience. That's dig toxicity, call somebody.

Pregnancy and pediatric red flags

One-liner questions that everyone gets wrong once.

Memory trick

No ACE inhibitors, ARBs, warfarin, isotretinoin, or tetracyclines in pregnancy. No aspirin in kids with a viral illness (Reye's). No tetracyclines under age 8 (teeth).

Dosage calc without spiraling

You lose these points to arithmetic, not knowledge.

Memory trick

Desired / Have ร— Volume. For drips: (mL/hr) = (dose ร— weight ร— 60) / concentration. Always write the units in the equation and cancel them โ€” if the units don't cancel, the answer is wrong before you ever divide.

Label your units. Unlabeled math is how patients get 10ร— doses.

Keep going

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